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KMID : 0363620050260030055
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Journal of Korean Oriental Medicine
2005 Volume.26 No. 3 p.55 ~ p.65
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The Effects of Psoraleae fructus Extract on Melanin Synthesis of B16 Melanoma Cells
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Abstract
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Objectives : This study was carried out for the development of medicine for vitiligo treatment and focused on the effect of Psoraleae fructus extract on melanin synthesis of B16 melanoma cells.
Methods : Activity of tyrosinase playing a vital role in the synthesis and quantity of melanin, which is the final product in cultured B16 melanoma cells, the effects of Psoraleae fructus extract were measured.
Results : The results indicated that Psoraleae fructus extract increased beth the amount of melanin and the activity of tyrosinase according to concentration, also supported by western blot analysis.
Conclusions : The results suggest that Psoraleae fructus extract has an advantageous effect on the promotion of melanin synthesis and will contribute to the development of vitiligo treatment through further related studies.
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